R&D Wingfield Bibliography

  • Purity

    >97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

  • Endotoxin Level

  • Activity

    Measured in a cell proliferation assay using PHA-activated mouse splenocytes. Mattner, F. et al. (1993) Eur. J. Immunol. 23:2202. The ED50 for this effect is 0.01-0.1 ng/mL.

  • Source

    Spodoptera frugiperda, Sf 21 (baculovirus)-derived
    Mouse IL-12 p40
    (Met23-Ser335)
    Accession # P43432
    Mouse IL-12 p35
    (Arg23-Ala215)
    Accession # NP_032377
    N-terminusC-terminus
  • Accession #

    P43432 (p40) & NP_032377 (p35)

  • N-terminal Sequence
    Analysis

    Met23 (p40) & Arg23 (p35)

  • Structure / Form

    Disulfide-linked heterodimer

  • SDS-PAGE

    70 kDa, non-reducing conditions

Product Datasheets

Certificate of Analysis Lookup

Certificate of Analysis Lookup

Certificate of Analysis Request Form

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

419-ML

 

419-ML/CF

Formulation Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.

Formulation Lyophilized from a 0.2 μm filtered solution in PBS.

Reconstitution Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.

Reconstitution Reconstitute at 100 μg/mL in sterile PBS.

Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage:Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Stability & Storage:Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

Data Images

Recombinant Mouse IL-12 (Catalog # 419‑ML) stimulates cell proliferation of PHA-activated mouse splenocytes. The ED50 for this effect is 0.01‑0.1 ng/mL.
1 μg/lane of Recombinant Mouse IL-12 was resolved with SDS-PAGE under reducing (R) and non-reducing (NR) conditions and visualized by silver staining, showing bands at 25 kDa and 43 kDa (R) and 68 kDa (NR).

Background: IL-12

Interleukin 12, also known as Natural Killer Cell Stimulatory Factor (NKSF) or Cytotoxic Lymphocyte Maturation Factor (CLMF), is a heterodimeric pleiotropic cytokine made up of a 40 kDa (p40) subunit and a 35 kDa (p35) subunit. IL‑12 is produced by macrophages and B lymphocytes and has been shown to have multiple effects on T cells and Natural Killer (NK) cells. Some of these IL‑12 activities include the induction of IFN‑ gamma and TNF in resting and activated T and NK cells; the enhancement of cytotoxic activity of resting NK and T cells, the stimulation of resting T cell proliferation in the presence of a comitogen; and the enhancement of NK cell proliferation. Current evidence indicates that IL‑12 is a key mediator of cellular-immunity and induces the differentiation of Th1 cells from precursor T helper cells. Based on its activities, it has been suggested that IL‑12 may have therapeutic potential as a vaccine adjuvant that promotes cellular-immunity and as an anti-tumor and anti-viral agent.

Human and mouse IL‑12 share 70% and 60% amino acid sequence identity in their p40 and p35 subunits, respectively. While mouse IL‑12 is active on both human and mouse cells, human IL‑12 is not active on murine cells. R&D Systems' recombinant mouse IL‑12 preparations were proteolytically cleaved between residues G158 and E159 of the mature p35 subunit. Thus, under reducing conditions, three bands representing the p40 subunit, the p35 R1 ‑ G158 peptide and the p35 E159 - A193 peptide can be observed in SDS-PAGE. The biological activity of this cleaved mouse IL‑12 is comparable to that of the intact human IL‑12.

  • Long Name:

  • Entrez Gene IDs:

    3592 (Human); 16159 (Mouse); 84405 (Rat); 403977 (Canine); 493741 (Feline)

  • Alternate Names:

    CLMF p35; CLMF1; Cytotoxic lymphocyte maturation factor 35 kDa subunit; IL-12 subunit p35; IL12; IL-12; IL-12, subunit p35; IL12A; interleukin 12, p35; interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocytematuration factor 1, p35); interleukin-12 alpha chain; interleukin-12 subunit alpha; natural killer cell stimulatory factor 1, 35 kD subunit; NF cell stimulatory factor chain 1; NK cell stimulatory factor chain 1; NKSF1; p35

Related Research Areas

Citations:

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

158 Citations: Showing 1 - 10
Filter your results:

Species
Applications
Sample Type
  1. Generating the Abscopal Effect by Combining Proapoptotic Peptides With IL-12-Based Immunotherapy
    Authors: F Martins, G Stalder, M Obeid
    Neoplasia, 2017;20(2):193-196.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  2. The transcriptional coactivator TAZ regulates reciprocal differentiation of TH17 cells and Treg cells
    Authors: J Geng, S Yu, H Zhao, X Sun, X Li, P Wang, X Xiong, L Hong, C Xie, J Gao, Y Shi, J Peng, RL Johnson, N Xiao, L Lu, J Han, D Zhou, L Chen
    Nat. Immunol., 2017;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  3. Dual role of ALCAM in neuroinflammation and blood-brain barrier homeostasis
    Authors: MA L‚cuyer, O Saint-Laur, L BourbonniŠ, S Larouche, C Larochelle, L Michel, M Charabati, M Abadier, S Zandee, N Haghayegh, E Gowing, C Pittet, R Lyck, B Engelhardt, A Prat
    Proc. Natl. Acad. Sci. U.S.A, 2017;114(4):E524-E533.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  4. Armc5 deletion causes developmental defects and compromises T-cell immune responses
    Authors: Y Hu, L Lao, J Mao, W Jin, H Luo, T Charpentie, S Qi, J Peng, B Hu, MM Marcinkiew, A Lamarre, J Wu
    Nat Commun, 2017;8(0):13834.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  5. Hypoxia Enhances Immunosuppression by Inhibiting CD4+ Effector T Cell Function and Promoting Treg Activity
    Authors: AM Westendorf, K Skibbe, A Adamczyk, J Buer, R Geffers, W Hansen, E Pastille, V Jendrossek
    Cell. Physiol. Biochem, 2017;41(4):1271-1284.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  6. Absence of Notch1 in murine myeloid cells attenuates the development of experimental autoimmune encephalomyelitis by affecting Th1 and Th17 priming
    Authors: M Fernández, EM Monsalve, S López-Lópe, A Ruiz-Garcí, S Mellado, E Caminos, JJ García-Ram, J Laborda, P Tranque, MJM Díaz-Guerr
    Eur. J. Immunol., 2017;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  7. Dectin 1 activation on macrophages by galectin 9 promotes pancreatic carcinoma and peritumoral immune tolerance
    Authors: D Daley, VR Mani, N Mohan, N Akkad, A Ochi, DW Heindel, KB Lee, CP Zambirinis, GSB Pandian, S Savadkar, A Torres-Her, S Nayak, D Wang, M Hundeyin, B Diskin, B Aykut, G Werba, RM Barilla, R Rodriguez, S Chang, L Gardner, LK Mahal, B Ueberheide, G Miller
    Nat. Med., 2017;23(5):556-567.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  8. Lamtor1 Is Critically Required for CD4(+) T Cell Proliferation and Regulatory T Cell Suppressive Function
    Authors: T Hosokawa, T Kimura, S Nada, T Okuno, D Ito, S Kang, S Nojima, K Yamashita, T Nakatani, Y Hayama, Y Kato, Y Kinehara, M Nishide, N Mikami, S Koyama, H Takamatsu, D Okuzaki, N Ohkura, S Sakaguchi, M Okada, A Kumanogoh
    J. Immunol., 2017;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  9. Manipulating Glucose Metabolism during Different Stages of Viral Pathogenesis Can Have either Detrimental or Beneficial Effects
    Authors: SK Varanasi, D Donohoe, U Jaggi, BT Rouse
    J. Immunol., 2017;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  10. Gut memories do not fade: epigenetic regulation of lasting gut homing receptor expression in CD4(+) memory T cells
    Authors: BA Szilagyi, J Triebus, C Kressler, M de Almeida, S Tierling, P Durek, M Mardahl, A Szilagyi, S Floess, J Huehn, U Syrbe, J Walter, JK Polansky, A Hamann
    Mucosal Immunol, 2017;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  11. BACH2 immunodeficiency illustrates an association between super-enhancers and haploinsufficiency
    Authors: B Afzali, J Grönholm, J Vandrovcov, C O'Brien, HW Sun, I Vanderleyd, FP Davis, A Khoder, Y Zhang, AN Hegazy, AV Villarino, IW Palmer, J Kaufman, NR Watts, M Kazemian, O Kamenyeva, J Keith, A Sayed, D Kasperavic, M Mueller, JD Hughes, IJ Fuss, MF Sadiyah, K Montgomery, J McElwee, NP Restifo, W Strober, MA Linterman, PT Wingfield, HH Uhlig, R Roychoudhu, TJ Aitman, P Kelleher, MJ Lenardo, JJ O'Shea, N Cooper, ADJ Laurence
    Nat. Immunol., 2017;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  12. Egr2 and 3 Inhibit T-bet-Mediated IFN-? Production in T Cells
    Authors: R Singh, T Miao, ALJ Symonds, B Omodho, S Li, P Wang
    J. Immunol., 2017;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  13. A role for cathepsin Z in neuroinflammation provides mechanistic support for an epigenetic risk factor in multiple sclerosis
    Authors: ERO Allan, RI Campden, BW Ewanchuk, P Tailor, DR Balce, NT McKenna, CJ Greene, AL Warren, T Reinheckel, RM Yates
    J Neuroinflammation, 2017;14(1):103.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  14. Induction of Colonic Regulatory T Cells by Mesalamine by Activating the Aryl Hydrocarbon Receptor
    Authors: K Oh-Oka, Y Kojima, K Uchida, K Yoda, K Ishimaru, S Nakajima, J Hemmi, H Kano, Y Fujii-Kuri, R Katoh, H Ito, A Nakao
    Cell Mol Gastroenterol Hepatol, 2017;4(1):135-151.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  15. TLR7 Signaling Regulates Th17 Cells and Autoimmunity: Novel Potential for Autoimmune Therapy
    Authors: J Ye, Y Wang, X Liu, L Li, A Opejin, EC Hsueh, H Luo, T Wang, D Hawiger, G Peng
    J. Immunol., 2017;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  16. The RNA-binding protein HuR contributes to neuroinflammation by promoting C-C chemokine receptor 6 (CCR6) expression on Th17 cells
    Authors: J Chen, JL Martindale, C Cramer, M Gorospe, U Atasoy, PD Drew, S Yu
    J. Biol. Chem., 2017;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  17. Integrated STAT3 and Ikaros Zinc Finger Transcription Factor Activities Regulate Bcl-6 Expression in CD4(+) Th Cells
    Authors: KA Read, MD Powell, CE Baker, BK Sreekumar, VM Ringel-Sca, H Bachus, RE Martin, ID Cooley, IC Allen, A Ballestero, KJ Oestreich
    J. Immunol., 2017;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  18. A Murine Intestinal Intraepithelial NKp46-Negative Innate Lymphoid Cell Population Characterized by Group 1 Properties
    Authors: A Van Acker, K Gronke, A Biswas, L Martens, Y Saeys, J Filtjens, S Taveirne, E Van Ammel, T Kerre, P Matthys, T Taghon, B Vandekerck, J Plum, IR Dunay, A Diefenbach, G Leclercq
    Cell Rep, 2017;19(7):1431-1443.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  19. Blood coagulation factor XII drives adaptive immunity during neuroinflammation via CD87-mediated modulation of dendritic cells
    Nat Commun, 2016;7(0):11626.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  20. T cells are necessary for ILC2 activation in house dust mite-induced allergic airway inflammation in mice
    Authors: BW Li, MJ de Bruijn, I Tindemans, M Lukkes, A KleinJan, HC Hoogsteden, RW Hendriks
    Eur J Immunol, 2016;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  21. IL-18R?-deficient CD4(+) T cells induce intestinal inflammation in the CD45RB(hi) transfer model of colitis despite impaired innate responsiveness
    Authors: P Holmkvist, L Pool, K Hägerbrand, WW Agace, A Rivollier
    Eur J Immunol, 2016;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  22. Interleukin-12 inhibits pathological neovascularization in mouse model of oxygen-induced retinopathy
    Authors: Yedi Zhou
    Sci Rep, 2016;6(0):28140.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  23. Adaptive immunity against gut microbiota enhances apoE-mediated immune regulation and reduces atherosclerosis and western-diet-related inflammation
    Sci Rep, 2016;6(0):29353.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  24. Blockade of Extracellular ATP Effect by Oxidized ATP Effectively Mitigated Induced Mouse Experimental Autoimmune Uveitis (EAU)
    PLoS ONE, 2016;11(5):e0155953.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  25. Conditioned Medium from the Stem Cells of Human Exfoliated Deciduous Teeth Ameliorates Experimental Autoimmune Encephalomyelitis
    Authors: C Shimojima, H Takeuchi, S Jin, B Parajuli, H Hattori, A Suzumura, H Hibi, M Ueda, A Yamamoto
    J Immunol, 2016;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  26. Immune signatures of protective spleen memory CD8 T cells
    Sci Rep, 2016;6(0):37651.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  27. Dimethyl fumarate treatment induces adaptive and innate immune modulation independent of Nrf2
    Authors: U Schulze-To, M Varrin-Doy, K Pekarek, CM Spencer, A Shetty, SA Sagan, BA Cree, RA Sobel, BT Wipke, L Steinman, RH Scannevin, SS Zamvil
    Proc Natl Acad Sci USA, 2016;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  28. Myelin-specific Th17 cells induce severe relapsing optic neuritis with irreversible loss of retinal ganglion cells in C57BL/6 mice
    Authors: CM Larabee, Y Hu, S Desai, C Georgescu, JD Wren, RC Axtell, SM Plafker
    Mol Vis, 2016;22(0):332-41.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  29. Inflammation enhances the vaccination potential of CD40-activated B cells in mice
    Eur. J. Immunol., 2016;0(0):2016.
    Species: Mouse
    Sample Type: In Vivo
  30. Autoantibody-boosted T-cell reactivation in the target organ triggers manifestation of autoimmune CNS disease
    Proc. Natl. Acad. Sci. U.S.A., 2016;113(12):3323-8.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  31. Th1 cells downregulate connexin 43 gap junctions in astrocytes via microglial activation
    Sci Rep, 2016;6(0):38387.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  32. Attenuation of PKR-like ER Kinase (PERK) Signaling Selectively Controls Endoplasmic Reticulum Stress-induced Inflammation Without Compromising Immunological Responses
    Authors: LN Guthrie, K Abiraman, ES Plyler, NT Sprenkle, SA Gibson, BC McFarland, R Rajbhandar, AL Rowse, EN Benveniste, GP Meares
    J. Biol. Chem., 2016;291(30):15830-40.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  33. p(70S6K1) in the TORC1 pathway is essential for the differentiation of Th17 Cells, but not Th1, Th2, or Treg cells in mice.
    Authors: Sasaki C, Chen G, Munk R, Eitan E, Martindale J, Longo D, Ghosh P
    Eur J Immunol, 2016;46(1):212-22.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  34. Mesothelin-specific cell-based vaccine generates antigen-specific immunity and potent antitumor effects by combining with IL-12 immunomodulator.
    Authors: Chang M, Chen Y, Chiang Y, Chen T, Tang Y, Chen C, Sun W, Cheng W
    Gene Ther, 2016;23(1):38-49.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  35. RGS10 deficiency ameliorates the severity of disease in experimental autoimmune encephalomyelitis.
    Authors: Lee J, Kannarkat G, Chung J, Joon Lee H, Graham K, Tansey M
    J Neuroinflammation, 2016;13(1):24.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  36. IkappaBNS regulates murine Th17 differentiation during gut inflammation and infection.
    Authors: Annemann M, Wang Z, Plaza-Sirvent C, Glauben R, Schuster M, Ewald Sander F, Mamareli P, Kuhl A, Siegmund B, Lochner M, Schmitz I
    J Immunol, 2015;194(6):2888-98.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  37. Identification and Analysis of Natural Killer Cells in Murine Nasal Passages.
    Authors: Okada K, Sato S, Sato A, Mandelboim O, Yamasoba T, Kiyono H
    PLoS ONE, 2015;10(11):e0142920.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  38. MHCII-independent CD4+ T cells protect injured CNS neurons via IL-4.
    Authors: Walsh J, Hendrix S, Boato F, Smirnov I, Zheng J, Lukens J, Gadani S, Hechler D, Golz G, Rosenberger K, Kammertons T, Vogt J, Vogelaar C, Siffrin V, Radjavi A, Fernandez-Castaneda A, Gaultier A, Gold R, Kanneganti T, Nitsch R, Zipp F, Kipnis J
    J Clin Invest, 2015;125(2):699-714.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  39. Interleukin-36gamma is expressed by neutrophils and can activate microglia, but has no role in experimental autoimmune encephalomyelitis.
    Authors: Bozoyan L, Dumas A, Patenaude A, Vallieres L
    J Neuroinflammation, 2015;12(0):173.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  40. Immune requirements for protective Th17 recall responses to Mycobacterium tuberculosis challenge.
    Authors: Monin L, Griffiths K, Slight S, Lin Y, Rangel-Moreno J, Khader S
    Mucosal Immunol, 2015;8(5):1099-109.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  41. Adaptive Immune-like gamma/delta T Lymphocytes Share Many Common Features with Their alpha/beta T Cell Counterparts.
    Authors: Lombes A, Durand A, Charvet C, Riviere M, Bonilla N, Auffray C, Lucas B, Martin B
    J Immunol, 2015;195(4):1449-58.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  42. Dynamics of Circulating gammadelta T Cell Activity in an Immunocompetent Mouse Model of High-Grade Glioma.
    Authors: Beck B, Kim H, O'Brien R, Jadus M, Gillespie G, Cloud G, Hoa N, Langford C, Lopez R, Harkins L, Lamb L
    PLoS ONE, 2015;10(5):e0122387.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  43. Effector T Cell Egress via Afferent Lymph Modulates Local Tissue Inflammation.
    Authors: Gomez D, Diehl M, Crosby E, Weinkopff T, Debes G
    J Immunol, 2015;195(8):3531-6.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  44. IL-33 receptor ST2 amplifies the expansion of NK cells and enhances host defense during mouse cytomegalovirus infection.
    Authors: Nabekura T, Girard J, Lanier L
    J Immunol, 2015;194(12):5948-52.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  45. CXCL13 antibody for the treatment of autoimmune disorders.
    Authors: Klimatcheva E, Pandina T, Reilly C, Torno S, Bussler H, Scrivens M, Jonason A, Mallow C, Doherty M, Paris M, Smith E, Zauderer M
    BMC Immunol, 2015;16(0):6.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  46. DNA-dependent protein kinase inhibition blocks asthma in mice and modulates human endothelial and CD4(+) T-cell function without causing severe combined immunodeficiency.
    Authors: Ghonim M, Pyakurel K, Ju J, Rodriguez P, Lammi M, Davis C, Abughazleh M, Mansy M, Naura A, Boulares A
    J Allergy Clin Immunol, 2015;135(2):425-40.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  47. ROR inverse agonist suppresses insulitis and prevents hyperglycemia in a mouse model of type 1 diabetes.
    Authors: Solt L, Banerjee S, Campbell S, Kamenecka T, Burris T
    Endocrinology, 2015;156(3):869-81.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  48. An IL-27/NFIL3 signalling axis drives Tim-3 and IL-10 expression and T-cell dysfunction.
    Authors: Zhu C, Sakuishi K, Xiao S, Sun Z, Zaghouani S, Gu G, Wang C, Tan D, Wu C, Rangachari M, Pertel T, Jin H, Ahmed R, Anderson A, Kuchroo V
    Nat Commun, 2015;6(0):6072.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  49. Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells.
    Authors: Rutz S, Kayagaki N, Phung Q, Eidenschenk C, Noubade R, Wang X, Lesch J, Lu R, Newton K, Huang O, Cochran A, Vasser M, Fauber B, DeVoss J, Webster J, Diehl L, Modrusan Z, Kirkpatrick D, Lill J, Ouyang W, Dixit V
    Nature, 2015;518(7539):417-21.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  50. TGF-beta3-expressing CD4+CD25(-)LAG3+ regulatory T cells control humoral immune responses.
    Authors: Okamura T, Sumitomo S, Morita K, Iwasaki Y, Inoue M, Nakachi S, Komai T, Shoda H, Miyazaki J, Fujio K, Yamamoto K
    Nat Commun, 2015;6(0):6329.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  51. miR-148a is upregulated by Twist1 and T-bet and promotes Th1-cell survival by regulating the proapoptotic gene Bim.
    Authors: Haftmann C, Stittrich A, Zimmermann J, Fang Z, Hradilkova K, Bardua M, Westendorf K, Heinz G, Riedel R, Siede J, Lehmann K, Weinberger E, Zimmel D, Lauer U, Haupl T, Sieper J, Backhaus M, Neumann C, Hoffmann U, Porstner M, Chen W, Grun J, Baumgrass R, Matz M, Lohning M, Scheffold A, Wittmann J, Chang H, Rajewsky N, Jack H, Radbruch A, Mashreghi M

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